Congenital Hyperinsulinism—Hypoglycemia

Also called: Low blood sugar

Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose.

In most people, this raises blood sugar. If it doesn’t, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include

• Hunger
• Shakiness
• Dizziness
• Confusion
• Difficulty speaking
• Feeling anxious or weak

In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan.

You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

• Diabetes – low blood sugar – self-care (Medical Encyclopedia)
• Drug-induced hypoglycemia (Medical Encyclopedia)
• Insulin C-peptide (Medical Encyclopedia)
• Low blood sugar (Medical Encyclopedia)
• Low blood sugar – newborns (Medical Encyclopedia)

Congenital hyperinsulinism is a condition that causes individuals to have abnormally high levels of insulin, which is a hormone that helps control blood sugar levels. People with this condition have frequent episodes of low blood sugar (hypoglycemia). In infants and young children, these episodes are characterized by a lack of energy (lethargy), irritability, or difficulty feeding. Repeated episodes of low blood sugar increase the risk for serious complications such as breathing difficulties, seizures, intellectual disability, vision loss, brain damage, and coma.The severity of congenital hyperinsulinism varies widely among affected individuals, even among members of the same family. About 60 percent of infants with this condition experience a hypoglycemic episode within the first month of life. Other affected children develop hypoglycemia by early childhood. Unlike typical episodes of hypoglycemia, which occur most often after periods without food (fasting) or after exercising, episodes of hypoglycemia in people with congenital hyperinsulinism can also occur after eating.